Researchers from King's College, University of London, UK, for the first time clarified the natural regeneration ability of a group of stem cells present in the heart. New research confirms that these cells are responsible for repairing and regenerating myocardial tissue damaged by a heart attack. The new study, published in the August 15 issue of Cell, shows that if these stem cells are removed, the heart will not be repaired after the injury. If these heart stem cells can be replaced with heart repair, the heart cells, structure and function can be completely restored, and the heart can return to normal to pump blood at a regular rate. And if these heart stem cells are removed and reinfused, they will naturally return and repair the damaged heart. This study found that it may lead to minimally invasive treatment in the future and even prevent heart failure early. In this study, the researchers determined the role of these cardiac stem cells (eCSCs) in the heart of rodent heart for the first time by removing them. The removal of these cells prevented heart regeneration and recovery, confirming that these cells can respond to heart failure to repair the heart's intrinsic regeneration capacity. Heart failure occurs when the heart cannot fully pump blood to the whole body, and more than 750,000 people in the UK are affected by the disease, causing patients to have difficulty breathing and affecting their daily activities. Current treatments are mainly aimed at potential causes, such as treatment of coronary heart disease, heart attack and blood pressure through lifestyle changes and drugs, and surgical treatment in some serious cases. These treatments can sometimes successfully prevent or delay heart failure. But once heart failure occurs, the only treatment is heart transplantation. By revealing this powerful homing mechanism that causes cardiac stem cells to return and repair the damaged heart muscle, new research findings will prompt the development of minimally invasive therapies, or preventive measures, to maintain and increase the activity of the heart's own stem cells. The first author of the paper, Dr. Georgina Ellison and senior author Bernardo Nadal-Ginard, worked at the Stem Cell and Regenerative Medicine Center and the Human and Aerospace Physiological Science Center at King ’s College London. They said: "In a healthy heart, the number of cardiac stem cells is sufficient to repair the heart ’s myocardial tissue. In a damaged heart, many cardiac stem cells cannot proliferate or generate new myocardial tissue. In these cases, by Cultivating these cells in the laboratory and administering them intravenously may replace damaged heart stem cells or add new cells. " Dr. Ellison said: "Understanding the role and potential of cardiac stem cells may pave the way for the development of new methods to prevent and treat heart failure. These methods can maintain or increase the activity of cardiac stem cells and enable new heart cells to renew the heart The myocardial tissue in the heart can increase senescent cells or deplete damaged cells. " "Because the heart is their home, these cardiac stem cells will naturally return to the heart, and they know where to go. The current major surgical operations mainly involve intramyocardial or intracoronary injections. Our research confirms this homing The mechanism may lead to minimally invasive treatment of cardiac stem cells by intravenous injection. "Professor Nadal-Ginard said:" Although this is only an early study, our results are very promising. The next work includes the 2014 A clinical trial was launched early this year to assess the effectiveness of heart stem cells in preventing and treating human heart failure. " Made of supreme quality EVA material, water resistant, moisture proofing and dust-proof. Watch Travel Case ,Custom Watch Case,Eva Watch Case,Eva Hard Watch Case Shenzhen Guohui Craft Products Co.,Ltd. , https://www.evacarrycase.com
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