High-sensitivity cardiac troponin T predicts better long-term death

A European study showed that high-sensitivity cardiac troponin T (hs-cTnT) is more accurate than high-sensitivity cardiac troponin I (hs-cTnI) in predicting long-term death. The paper was published online in "Eur Heart J" on July 2nd.

A total of 1117 patients with non-selective acute chest pain were included in this study, and three new methods and one traditional method were used to determine cardiac troponin in a blinded manner. Patients were followed up for 2 years on the death status. A total of 82 patients (7.3%) died during the follow-up period.

The results show that the 2-year prediction accuracy of hs-cTnT is the highest (AUC 0.78), and is superior to hs-cTnI and cardiac troponin T (cTnT). In terms of predicting mortality, the accuracy of the absolute change in hs-cTnT to predict death is worse than the relative change in hs-cTnT, but not as good as the current value of hs-cTnT. The combination of changes in hs-cTnT and present value within 6 hours failed to further improve the prediction accuracy. In subgroups of patients with pre-existing coronary artery disease, impaired renal function, and age> 75 years who are clinically difficult to predict, hs-cTn concentration remains a predictor of death.


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