The United States developed a semi-mechanical body tissue with nanoelectronic materials

The United States has developed semi-mechanical body tissues with nanoelectronic materials. Harvard University of the United States claims that its scientists have successfully developed a new technology that can implant a functional, biocompatible nanoscale three-dimensional network into engineered human tissue. For the first time, a semi-mechanical structure was developed. After this nano-scale "scaffold" is implanted into the body together with the cells, it can develop into a body-identified tissue that can be used to detect changes in cell activity inside the body without any adverse reactions. A long-term concern related to bioengineering organizations is how to develop a system that can sense the chemical or electrical changes of the body tissue after it is implanted into the body, and can also provide a method for researchers to directly Stimulate engineered tissue and measure cell response. "Currently, our methods for monitoring and intervening life systems are very limited. Only electrodes can be used to measure the activity in cells or tissues, but this will harm the cells and tissues." Charles M. Lieber, the project leader and Harvard professor of chemistry Say, "With this new technology, we can perform the same operations on the same level of biological systems without harming them. Of course, the most difficult thing about merging organizations with electronic devices is how to combine the bottom of the organization with The tops of the electronic devices are connected. "The research started with finding a two-dimensional matrix. First, the researchers wound the organic polymer mesh around the nanowire as an important sensing element; then, a nanoelectrode connected to the nanowire sensing element was built in the mesh to enable the nanowire transistor to measure the cell's Move without hurting them. In this way, the problem of the two-dimensional matrix is ​​solved. The mesh sponge body (or mesh) obtained by the researchers can be folded or curled into the three-dimensional body to be entered. The construction process of the mesh is similar to the etching process of the microchip. Because the autonomic nervous system records the pH, chemistry, oxygen, and other elements in the body and responds when needed, the researchers chose to use the autonomic nervous system to build nanowires. Using heart cells and nerve cells, the researchers successfully implanted the nano-mesh into the tissue without affecting the development and activity of the cells in the tissue; by using the method of implanting the device, the researchers can detect the electricity emitted by deep cells in the tissue Signal, and measure the signal changes caused by drugs in the heart and nerve tissue. They said that using this technology can also measure the pH value of implanted bioengineered blood vessels and the changes in other biochemical or cellular environments, such as the response to inflammation and ischemia. The researchers believe that there are many potential application fields of this technological achievement, which can be used in the pharmaceutical industry in the near future. Researchers can use the technology to study the latest developments in the role of drugs more accurately on three-dimensional tissues rather than thin layers of cell culture. In the future, the technology can also be used to detect the internal changes and corresponding responses of the human body to electrical stimulation or drugs.

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